Skip to main content

What about the unattached cell?

While this procedure is not what I had in mind when I spoke of being able to reprogram the cancer cell, I'm nevertheless glad that reprogramming was found to be possible for the unattached cancer cell. The unattached immune cell is needed everywhere in the body and it would make sense for a cancer derived from an immune cell to differentiate into other immune cells as needed. This is what was found by the Stanford researchers--reprogramming of leukemia cells into normal granulocytes and macrophages via supplied ligands or transcription factors. The initial observation from Stanford came about as a result of a shotgun approach. This approach should also be used for the solid tumor and if their cocktail doesn't do it, I would consider extracting Embryonic Cell Surface molecules from various developmental time points.

Finding the right CRF for the differentiation of  solid tumors is right around the corner.

My next post will be one showing what the CRF theory helps explain when it comes to cancer biology.

One major question that I need to resolve is whether the CRF for solid tumors is found between neighboring cells on their cell membranes or on what could be tissue-specific ECM's or on both.
Labels:

Comments

Post a Comment

Popular posts from this blog

Biological Pathways Symbology

Post a Comment
Read more
Tumorigenesis: Actions to initiate the cancer state. The Cell Recognition Factor theory of cancer maintains that detachment of a cell from its neighbors is necessary for most cancers to arise. After that, a malfunction or replenishment of the telomere, or a reversion to stem cell, is necessary to permit the growth of cancer cells. The immune system then comes into play in keeping cancer cells in check or in promoting their elimination. A daughter cell has three additional hurdles to overcome on its road to cancer. It must eliminate the threat of apoptosis; eliminate telomere degradation; and, prevent itself from ending up in an inhospitable environment away from resources. I. Stem cell (immortal) . a. Detach from neighbors . b. Escape from Immune Surveillance II. Daughter cell (specialized, mortal) . a. Detach from neighbors . b. Escape from Immune Surveillance . c. Prevent Apoptosis . d. Stop Degradation of the Telomere . e. Prev...
1 comment
Read more

St. Peregrinus and CRF Theory

[ note: contains adult discussions of sexual matters which some non-biologists may find offensive ] St. Peregrinus is the patron saint of those suffering from cancer but his connection to this blog goes deeper than that, and it's something that I've been meaning to write about. if the CRF Theory demands a loss of communication between cells as the initiator of cancer, what role would physical factors play? I've refrained from discussing this because the evidence is very anecdotal. But let's start with the saint. In penance for his actions, he spent 30 years preferring standing to sitting, and he ended up with varicosities of the leg and, eventually, cancer of the foot which was so bad that an amputation was scheduled* The caveat that makes cancer etiology so difficult is that rarely does a single factor produce cancer for even when a single factor has a causal relationship, there are some who do not succumb to it. Multiple factors enter into the equation--the patien...
Post a Comment
Read more