Tumorigenesis: Actions to initiate the cancer state. The Cell Recognition Factor theory of cancer maintains that detachment of a cell from its neighbors is necessary for most cancers to arise. After that, a malfunction or replenishment of the telomere, or a reversion to stem cell, is necessary to permit the growth of cancer cells. The immune system then comes into play in keeping cancer cells in check or in promoting their elimination. A daughter cell has three additional hurdles to overcome on its road to cancer. It must eliminate the threat of apoptosis; eliminate telomere degradation; and, prevent itself from ending up in an inhospitable environment away from resources. I. Stem cell (immortal) . a. Detach from neighbors . b. Escape from Immune Surveillance II. Daughter cell (specialized, mortal) . a. Detach from neighbors . b. Escape from Immune Surveillance . c. Prevent Apoptosis . d. Stop Degradation of the Telomere . e. Prev...
A theory created to explain the fact that cancer cells turn back to normal when put in an embryo; it's called the cell recognition theory of cancer. Basically, a cell loses touch with its neighbor(s)or with the ECM. This releases the physical constraints on the nucleus which then cycles through earlier embryonic stages hoping to establish contact once again (it partially succeeds when it establishes a metastasis).
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