First division seals embryo fate
The writer of the article states that, "Mimicking totipotency is the holy grail of stem-cell research. If the underlying molecular signals can be identified, they might be used to transform older cells and tissues, which do not normally repair themselves. Studies such as Zernicka-Goetz's 'begin to provide clues', says Pedersen." This is simply not possible if my theory is correct for the mimicking of totipotency can only result in an embryo. In fact, the writer's next statement contradicts the possibility of the search for the holy grail:
The earliest embryonic stages "are very special", he adds, as cells can organize themselves into a complete embryo. Mouse embryonic stem cells used in experiments can be grown in culture only once they have reached the later, blastocyst stage. By this point, they have already lost the ability to self-organize and only form embryos if injected into an existing blastocyst.
It is not that they have lost the ability to self-organize; rather, they try to self-organize but do not get the necessary R factors to continue with their reprogramming.
The writer of the article states that, "Mimicking totipotency is the holy grail of stem-cell research. If the underlying molecular signals can be identified, they might be used to transform older cells and tissues, which do not normally repair themselves. Studies such as Zernicka-Goetz's 'begin to provide clues', says Pedersen." This is simply not possible if my theory is correct for the mimicking of totipotency can only result in an embryo. In fact, the writer's next statement contradicts the possibility of the search for the holy grail:
The earliest embryonic stages "are very special", he adds, as cells can organize themselves into a complete embryo. Mouse embryonic stem cells used in experiments can be grown in culture only once they have reached the later, blastocyst stage. By this point, they have already lost the ability to self-organize and only form embryos if injected into an existing blastocyst.
It is not that they have lost the ability to self-organize; rather, they try to self-organize but do not get the necessary R factors to continue with their reprogramming.
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