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So, the cancer cell determines that it is not where it is supposed to be. What does it need to do then? It must free itself from the tissue matrix in which it resides, and it does this by secreting proteases called degradomes, and, this causes the cancer cell to become "unglued" and begin its metastatic journey to other tissues. The CancerDegradome.org website will report on the latest advances in the characterization of these degradomes.
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