Skip to main content
PLoS Biology: Nanotubes Make Big Science This article reviews work done on TNT's or Tunneling Nanotubes that connect cells that are not in close proximity to each other. It seems to be a mechanism to ensure that cells that need to be together can do so when separated by large distances of up to several cell diameters. To envison developmental biology you have to think like a cell. If you had to connect with a particular cell you could send out diffusible signals but these may not provide the degree of accuracy that you require. In cases requiring greater accuracy, a cell could send out a TNT, connect after utilizing Recognition Factors and then influence the neighboring cell via the transfer of proteins and, apparently, even organelles (see article). One interesting note is that material does not travel within the nanotube--it's not a pipe--but on the surface of the TNT.

Comments

Popular posts from this blog

Biological Pathways Symbology

Tumorigenesis: Actions to initiate the cancer state. The Cell Recognition Factor theory of cancer maintains that detachment of a cell from its neighbors is necessary for most cancers to arise. After that, a malfunction or replenishment of the telomere, or a reversion to stem cell, is necessary to permit the growth of cancer cells. The immune system then comes into play in keeping cancer cells in check or in promoting their elimination. A daughter cell has three additional hurdles to overcome on its road to cancer. It must eliminate the threat of apoptosis; eliminate telomere degradation; and, prevent itself from ending up in an inhospitable environment away from resources. I. Stem cell (immortal) . a. Detach from neighbors . b. Escape from Immune Surveillance II. Daughter cell (specialized, mortal) . a. Detach from neighbors . b. Escape from Immune Surveillance . c. Prevent Apoptosis . d. Stop Degradation of the Telomere . e. Prev...

St. Peregrinus and CRF Theory

[ note: contains adult discussions of sexual matters which some non-biologists may find offensive ] St. Peregrinus is the patron saint of those suffering from cancer but his connection to this blog goes deeper than that, and it's something that I've been meaning to write about. if the CRF Theory demands a loss of communication between cells as the initiator of cancer, what role would physical factors play? I've refrained from discussing this because the evidence is very anecdotal. But let's start with the saint. In penance for his actions, he spent 30 years preferring standing to sitting, and he ended up with varicosities of the leg and, eventually, cancer of the foot which was so bad that an amputation was scheduled* The caveat that makes cancer etiology so difficult is that rarely does a single factor produce cancer for even when a single factor has a causal relationship, there are some who do not succumb to it. Multiple factors enter into the equation--the patien...