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Cancer that runs in families may be evolution in action. When an evolutionary change takes place, other cells may have to undergo simultaneous change. This is because no cell other than free-floating blood cells can remain unattached to at least one other cell. Blodd cells can do it because they are fully diffentiated as free-floating. Other cells need to know where they are and they do it by a kind of "hand-shaking" or lock/key mechanism (ie, what I have been calling Cell Recognition Factors.

If we accept the fact that cells need to communicate with their neighbors, we can see that evolutionary changes involving changes in stucture will result in cancer until such time that neighboring cells can provide the right signals. This explains why evolution is such a slow process no cell undergoing a change can completel it's change without another cell matching its CRF.
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