http://www.newscientist.com/article/mg21829224.800?cmpid=NLC|NSNS|2013-2006-GLOBAL&utm_medium=NLC&utm_source=NSNS#.UcNY-tjJjyC Naked mole rats are not prone to cancer. These animals also produce quite a bit of hyaluronan, a lubricant that helps them "glide" better through their underground tunnels. Although not mentioned by the authors, these findings support the CRF theory of cancer initiation. Apparently, if the tissues of the naked mole rats can glide past each other, you minimize tearing and cells do not lose contact with their neighbors. If a cell stays in contact with its neighbors, it has no reason to alter phenotype to that of a cancerous state. [note that hyaluronan is not exuded externally by the skin; instead, it permeates the ECM]. If the rats are engineered not to express hyaluronan, cancer then develops. However, exactly how cancer was produced in these rats was not reported. Hopefully, I'll be able to read the original work someday.
I don't know if I mentioned it elsewhere but I have noticed reports of pancreatic cancer in rough and tumble people like stunt men and others who may injure their abdominal organs to the point where tears take place and initiate cancer. The pancreas also produces many proteolytic enzymes that may result in loss of contact when injury occurs and the enzymes leak into interstitial areas. Along the same lines, children may be injuring their bones and bone marrow resulting childhood cancers.
I don't know if I mentioned it elsewhere but I have noticed reports of pancreatic cancer in rough and tumble people like stunt men and others who may injure their abdominal organs to the point where tears take place and initiate cancer. The pancreas also produces many proteolytic enzymes that may result in loss of contact when injury occurs and the enzymes leak into interstitial areas. Along the same lines, children may be injuring their bones and bone marrow resulting childhood cancers.
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